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Spurious Hb mass increases following exercise.

C E Gough1, A Eastwood, P U Saunders

  • 1Australian Institute of Sport, Physiology, Canberra, Australia. clare.gough@ausport.gov.au

International Journal of Sports Medicine
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

Total haemoglobin mass (Hb(mass)) may improve blood doping detection but is unreliable post-exercise. Ultra-endurance triathlons showed increased Hb(mass) and decreased haptoglobin, suggesting exercise may confound accuracy.

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Area of Science:

  • Sports Science
  • Exercise Physiology
  • Biochemistry

Background:

  • The Athlete Blood Passport (ABP) is crucial for detecting blood doping in sports.
  • Total haemoglobin mass (Hb(mass)) is a potential marker to enhance ABP sensitivity.
  • Concerns exist regarding the reliability of Hb(mass) measurements immediately after strenuous exercise.

Purpose of the Study:

  • To investigate the stability of total haemoglobin mass (Hb(mass)) following an ultra-endurance triathlon.
  • To assess the impact of extreme exercise on Hb(mass) measurements.
  • To evaluate potential confounding factors affecting Hb(mass) accuracy post-exercise.

Main Methods:

  • Total haemoglobin mass (Hb(mass)) was measured using carbon monoxide (CO) re-breathing in 26 male sub-elite triathletes (Racers) and 8 Controls.
  • Measurements were taken twice, 1-5 days apart, with Racers tested pre- and post-triathlon (1-3 hours after completion).
  • Serum haptoglobin and urine haemoglobin concentrations were measured to assess intravascular haemolysis.

Main Results:

  • Racers exhibited a 3.2% increase in Hb(mass) post-triathlon, while Controls showed a 0.5% decrease.
  • Serum haptoglobin concentration significantly decreased by 67% in Racers post-exercise, indicating intravascular haemolysis.
  • The observed increase in Hb(mass) in Racers contrasted with the decrease in haptoglobin, suggesting potential measurement unreliability.

Conclusions:

  • Ultra-endurance triathlon exercise may confound the accuracy of post-exercise Hb(mass) measurements.
  • Potential mechanisms for Hb(mass) alteration include splenic contraction or increased CO diffusion into muscle.
  • The reliability of Hb(mass) as an ABP marker requires careful consideration in the context of extreme exercise protocols.