Jove
Visualize
Contact Us

Related Concept Videos

Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

1.4K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.4K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.4K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.4K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

46.1K
VSEPR Theory for Determination of Electron Pair Geometries
46.1K
Controlled-Potential Coulometry: Electrolytic Methods01:17

Controlled-Potential Coulometry: Electrolytic Methods

733
Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential...
733
Prediction Intervals01:03

Prediction Intervals

3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K
Potential Energy00:52

Potential Energy

42.8K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ensuring continued access to essential inhaled respiratory medications: a call to action from the Inhaled Respiratory medicine Innovation and environmental Sustainability (IRIS) group.

The European respiratory journal·2026
Same author

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction.

Journal of visualized experiments : JoVE·2026
Same author

Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA).

ALTEX·2026
Same author

A quantitative definition for poorly soluble particles.

Particle and fibre toxicology·2026
Same author

Inclusion of a recovery period after pulse treatment in the primary human lymphocyte micronucleus assay covers potential cell cycle delays without loss of sensitivity.

Mutagenesis·2026
Same author

Combined assessment of transgenic rodent gene mutation and micronuclei formation by benzo[a]pyrene, N-ethyl-N-nitrosourea, 2,4-diaminotoluene and ethyl carbamate.

Mutation research. Genetic toxicology and environmental mutagenesis·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 10, 2026

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

22.0K

Non-animal test methods for predicting skin sensitization potentials.

Annette Mehling1, Tove Eriksson, Tobias Eltze

  • 1BASF Personal Care and Nutrition GmbH, Düsseldorf, Germany.

Archives of Toxicology
|June 19, 2012
PubMed
Summary

Developing reliable in vitro tests is crucial to replace animal testing for skin sensitizers. Combining data from various non-animal methods offers a promising approach for accurate hazard and potency assessments.

More Related Videos

Somatosensory Event-related Potentials from Orofacial Skin Stretch Stimulation
06:56

Somatosensory Event-related Potentials from Orofacial Skin Stretch Stimulation

Published on: December 18, 2015

13.8K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Related Experiment Videos

Last Updated: Feb 10, 2026

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

22.0K
Somatosensory Event-related Potentials from Orofacial Skin Stretch Stimulation
06:56

Somatosensory Event-related Potentials from Orofacial Skin Stretch Stimulation

Published on: December 18, 2015

13.8K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Area of Science:

  • Toxicology
  • Immunology
  • Dermatology

Background:

  • Contact allergies affect 15-20% of the population, with increasing prevalence.
  • Animal testing for skin sensitization is under scrutiny due to ethical concerns and regulatory bans (e.g., EU 2013).
  • There is an urgent need for predictive and robust in vitro alternatives to animal testing.

Purpose of the Study:

  • To review recent advancements in the development of in vitro tests for predicting skin sensitizers.
  • To discuss the current status of cell-based, in chemico, and in silico methods as alternatives to animal testing.
  • To highlight the necessity of integrating data from multiple non-animal test methods for reliable risk assessment.

Main Methods:

  • Summary of recent research on in vitro methods for skin sensitization testing.
  • Presentation of cell-based assays, in chemico methods, and in silico approaches.
  • Discussion of the strengths and limitations of each method.

Main Results:

  • Significant progress has been made in developing non-animal testing strategies.
  • In vitro tests aim to mimic complex interactions between chemicals and the immune system.
  • Combining data from diverse non-animal methods is essential for robust predictions.

Conclusions:

  • In vitro methods are advancing as viable alternatives to animal testing for skin sensitizers.
  • A integrated approach using multiple non-animal test data is key for reliable hazard and potency evaluation.
  • The future of skin sensitization assessment lies in the combination of various in vitro and in silico methodologies.