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An Effective Manual Deboning Method To Prepare Intact Mouse Nasal Tissue With Preserved Anatomical Organization
Published on: August 10, 2013
A clue in the nose.
Hussam Ammar1, Michael A Meyer
1University at Buffalo, State University at New York, Buffalo, New York, USA. h_ammar70@yahoo.com
BMJ Case Reports
|June 19, 2012
Summary
A spontaneous cerebrospinal fluid (CSF) leak caused recurrent meningitis in an obese woman. Endoscopic repair of a sphenoid sinus defect resolved the CSF rhinorrhoea and prevented further infections.
Area of Science:
- Neurology
- Otolaryngology
- Neurosurgery
Background:
- Spontaneous cerebrospinal fluid (CSF) leaks, particularly from the sphenoid sinus, can lead to recurrent meningitis.
- Obesity and elevated intracranial pressure are potential contributing factors to spontaneous CSF leaks.
Observation:
- A 50-year-old morbidly obese woman presented with recurrent septic meningitis.
- She reported a year-long watery nasal discharge with low glucose levels, indicative of CSF rhinorrhoea.
- Brain CT revealed an empty sella and a defect in the right posterior sphenoid sinus wall.
Findings:
- The patient was diagnosed with a spontaneous CSF leak.
- Elevated intracranial pressure was suspected as the cause of the skull base defect.
- Endoscopic surgery successfully repaired the bony defect in the sphenoid sinus.
Implications:
- Prompt diagnosis and surgical repair of CSF leaks are crucial for preventing meningitis.
- Understanding the role of elevated intracranial pressure in spontaneous CSF leaks can guide management.
- This case highlights the importance of considering spontaneous CSF leaks in patients with recurrent meningitis and nasal discharge.
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