Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
Redox Reactions01:27

Redox Reactions

Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redox-responsive liposomes aimed at nitroreductase for contents release.

Journal of liposome research·2025
Same author

Monitoring Molecular Interactions with Cell Membranes Using Time-Dependent Second Harmonic Generation Microscopy.

Biochemistry·2025
Same author

Influence of Temperature on Molecular Adsorption and Transport at Liposome Surfaces Studied by Molecular Dynamics Simulations and Second Harmonic Generation Spectroscopy.

The journal of physical chemistry. B·2021
Same author

Molecular Adsorption and Transport at Liposome Surfaces Studied by Molecular Dynamics Simulations and Second Harmonic Generation Spectroscopy.

The journal of physical chemistry. B·2019
Same author

Characteristics of ovarian cancer detection by a near-infrared fluorescent probe activated by human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1).

Oncotarget·2017
Same author

Cascade Reaction-Based, Near-Infrared Multiphoton Fluorescent Probe for the Selective Detection of Cysteine.

Analytical chemistry·2017
Same journal

Immunometabolomics Applied to Physical Exercise: Accomplishments and New Directions for Health Improvement.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Carbon Nanofibers for Mass-Producible Electrochemical Transducers for Point-of-Care Testing.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Application of Ambient Ionization Mass Spectrometry to the Analysis of <i>Cannabis</i>.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

From Function to Single Cells: Analytical Innovations in Islet Biology and Diabetes Research.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Quantum Cascade Laser-Based Vibrational Circular Dichroism Imaging for Chiral Biosensing.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
Same journal

Ion-Ion Chemistry for the Analysis of Biomolecular Ions via Tandem Mass Spectrometry: A Tutorial Review.

Annual review of analytical chemistry (Palo Alto, Calif.)·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Redox-responsive delivery systems.

Robin L McCarley1

  • 1Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803-1804, USA. tunnel@lsu.edu

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|June 20, 2012
PubMed
Summary
This summary is machine-generated.

Electron transfer triggers responsive delivery systems, particularly for drug delivery and analyte transport. This review focuses on redox-activated vesicles and micelles for controlled material release.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Related Experiment Videos

Last Updated: May 21, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Stimuli-responsive systems are crucial for targeted material transport and delivery.
  • Electron transfer is emerging as a key stimulus for advanced delivery applications.
  • Redox-activated systems offer advantages in simplicity and ease of construction.

Purpose of the Study:

  • To review vesicle- and micelle-based delivery systems activated by redox stimuli.
  • To highlight the potential of these systems in drug delivery and analyte transport.
  • To discuss the design principles and applications of redox-responsive vehicles.

Main Methods:

  • Literature review of redox-activated delivery systems.
  • Focus on vesicle- and micelle-based nanostructures.
  • Analysis of stimulus-responsive mechanisms.

Main Results:

  • Redox stimuli offer a versatile and controllable trigger for material release.
  • Vesicle and micelle systems demonstrate significant potential for controlled delivery.
  • The integration of redox-responsive trigger groups is key to system design.

Conclusions:

  • Redox-activated vesicle and micelle systems are promising for various applications.
  • These systems offer precise control over material release via electron transfer.
  • Further development can enhance their utility in drug delivery and separation technologies.