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Updated: May 21, 2026

A Contusion Model of Severe Spinal Cord Injury in Rats
10:00

A Contusion Model of Severe Spinal Cord Injury in Rats

Published on: August 17, 2013

Persistent polyuria in a rat spinal contusion model.

Patricia J Ward1, Charles H Hubscher

  • 1Department Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40292, USA.

Journal of Neurotrauma
|June 20, 2012
PubMed
Summary
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Polyuria after spinal cord injury (SCI) remains severe even in mild cases and is not reduced by step training. Current theories on the cause of post-SCI polyuria may be incomplete, requiring further investigation.

Area of Science:

  • Neuroscience
  • Urology
  • Rehabilitation Science

Background:

  • Polyuria following spinal cord injury (SCI) exacerbates bladder overdistention, complicating urinary tract management and triggering autonomic dysreflexia.
  • Current understanding suggests post-SCI polyuria stems from lower extremity edema due to vascular tone loss, leading to fluid excess.

Purpose of the Study:

  • To investigate the severity of polyuria across different severities of contusive SCI in rats.
  • To evaluate the efficacy of step training as an intervention to reduce post-SCI polyuria.

Main Methods:

  • Adult male rats with mild, moderate, or severe SCI were housed in metabolic cages for 24-hour urine collection pre- and post-injury (up to 6 weeks).
  • Assessments included urine/feces/food/water intake, body weight, residual urine volume, locomotor function, in-cage activity, and lesion histology.

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Last Updated: May 21, 2026

A Contusion Model of Severe Spinal Cord Injury in Rats
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A Contusion Model of Severe Spinal Cord Injury in Rats

Published on: August 17, 2013

Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
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Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model

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  • Step training (30 min/day, 6 days/week) was administered to the moderate SCI group.

    • Main Results:

    • SCI induced an immediate and significant increase (approx. 2.6-fold) in 24-hour urine collection starting as early as 3 days post-injury, persisting for 6 weeks across all injury severities.
    • Severe polyuria persisted even in mild SCI cases with significant recovery of locomotor and bladder function.
    • Step training did not reduce polyuria in the moderate SCI group.

    Conclusions:

    • Post-SCI polyuria is a severe condition present across all injury severities, independent of expected edema levels in milder injuries.
    • Step training is ineffective in mitigating polyuria following moderate SCI.
    • The current mechanistic hypothesis explaining post-SCI polyuria requires revision due to these findings.