Related Experiment Video
Updated: May 21, 2026
12:45
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Past, present and future of cardiac resynchronization
Claude Daubert1, Serge Cazeau, Philippe Ritter
1Service de cardiologie et maladies vasculaires, hôpital Pontchaillou-CHU, Rennes, France. jean-claude.daubert@chu-rennes.fr
Archives of Cardiovascular Diseases
|June 20, 2012
Summary
This review explores cardiac dyssynchrony and resynchronization therapy, highlighting French contributions to new hemodynamic indications and device development. It covers advancements in atrial, atrioventricular, and ventricular resynchronization, with some concepts awaiting further investigation.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Growing interest in cardiac dyssynchrony and resynchronization therapy (CRT).
- Exploration of new hemodynamic indications for cardiac stimulation.
- Key role of French investigators in conceptualization and device development.
Observation:
- Clinical observations driving new concepts in cardiac stimulation.
- Collaboration between researchers and industry for resynchronization devices.
- Evaluation of atrial, atrioventricular, and ventricular dyssynchrony.
Findings:
- Summary of recent knowledge and perspectives on cardiac dyssynchrony and resynchronization.
- Validation of some concepts through robust clinical evidence and scientific recommendations.
- Identification of less successful concepts that may warrant further attention.
Implications:
- Potential for improved hemodynamic function through advanced cardiac stimulation.
- Guidance for future research and development in CRT.
- Informing clinical practice and the formulation of scientific recommendations for dyssynchrony management.
More Related Videos
Related Concept Videos
01:29Cardiomyopathy V: Interprofessional Care
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
01:19Electrophysiology of Normal Cardiac Rhythm
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
01:30Cardiac Action Potential
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
01:27Heart Failure I: Introduction
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...