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Updated: May 21, 2026

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction
Published on: May 17, 2024
Pathogenesis of porcine reproductive and respiratory syndrome virus
Ranjni J Chand1, Benjamin R Trible, Raymond R R Rowland
1Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, United States.
Abstract:
Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.
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