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Updated: May 21, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
De novo thrombus on an atrial septal defect device 3 years after its implantation
Olawale O Olabiyi1, David L S Morales, Wayne J Franklin
1The Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, 6221 Fannin St MC-19345-C, Houston, TX 77030, USA. olabiyi@bcm.edu
Insights
Percutaneous closure of secundum atrial septal defects (ASD) can lead to rare, late complications. This case highlights device thrombus as a very late complication after ASD closure.
Area of Science:
- Cardiology
- Medical Devices
- Congenital Heart Disease
Background:
- Secundum atrial septal defect (ASD) is a common congenital heart defect (CHD), occurring in 1 in 1,500 live births.
- Percutaneous closure is a standard treatment for secundum ASDs.
- Early complications include device issues, arrhythmias, and thrombus formation.
Observation:
- This report details a patient experiencing a very late complication following percutaneous closure of a secundum ASD.
Findings:
- The patient developed device thrombus, a rare but significant late complication.
- This finding underscores the potential for delayed adverse events after ASD device closure.
Implications:
- Awareness of very late complications like device thrombus is crucial for long-term patient management.
- Further research may be needed to understand the mechanisms and prevention of late-onset device-related thrombosis.
Abstract:
The secundum atrial septal defect (ASD) is noted to occur in 1 per 1,500 live births and is the fourth most common congenital heart defect (CHD) [Anzai et al. in Am J Cardiol 93:426-431, 2004]. Early complications with percutaneous closure of secundum ASDs include device malposition and embolization, arrhythmias (primarily atrial fibrillation), pericardial effusion, residual shunt, and thrombus development on the left atrial disk [Chessa et al. in J Am Coll Cardiol 39:1061-1065, 2002, Co-Burn and William in Moss and Adams' Heart disease in infants, children and adolescents including fetus and young adults. Williams and Wilkins, Baltimore, 1995]. We present a patient with a very late complication of device thrombus after percutaneous secundum ASD device closure.
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