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Updated: May 21, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
HIV-associated opportunistic infections of the CNS
Ik Lin Tan1, Bryan R Smith, Gloria von Geldern
1HIV Neuroscience Program, Johns Hopkins University, Baltimore, MD 21287, USA.
Abstract:
Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
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