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Published on: August 25, 2017
Oxidative stress in chronic otitis media.
Elif Baysal1, Nurten Aksoy, Ferit Kara
1Department of Otolaryngology, Medical Faculty, Gaziantep University, Sahinbey, Gaziantep 27070, Turkey. baysalelif@yahoo.com
Summary
Oxidative stress and antioxidant imbalance are more pronounced in cholesteatoma, a benign tumor-like lesion in chronic otitis media. This imbalance is greater in cholesteatoma cases compared to chronic otitis media without cholesteatoma.
Area of Science:
- Otolaryngology
- Biochemistry
- Pathophysiology
Background:
- Chronic otitis media (COM) often involves cholesteatoma, a benign temporal bone lesion.
- The role of oxidative stress in COM and cholesteatoma pathogenesis requires further investigation.
Purpose of the Study:
- To investigate oxidative stress markers and antioxidant enzymes in patients with cholesteatomatous COM, noncholesteatomatous COM, and healthy controls.
- To compare the levels of oxidative stress and antioxidant status between these groups.
Main Methods:
- Prospective controlled trial involving 75 subjects: 25 with cholesteatomatous COM, 25 with noncholesteatomatous COM, and 25 healthy controls.
- Measurement of serum total oxidant status (TOS), oxidative stress index (OSI), total antioxidant status (TAS), and paraoxonase and arylesterase activity.
Main Results:
- Significantly increased serum TOS and OSI levels in both COM patient groups compared to controls.
- Significantly lower serum TAS levels and paraoxonase/arylesterase activity in COM patients versus controls.
- Greater oxidative stress (higher TOS/OSI) and lower antioxidant status (lower TAS) observed in cholesteatomatous COM compared to noncholesteatomatous COM.
Conclusions:
- Oxidative stress and antioxidant enzyme imbalance are significantly associated with chronic otitis media.
- The degree of oxidative stress and antioxidant imbalance is more severe in cholesteatomatous chronic otitis media than in noncholesteatomatous chronic otitis media.
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