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Updated: May 21, 2026
08:20
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
Pathogenesis of colonic diverticular disease
Burkhard H A von Rahden1, Christoph-Thomas Germer
1Department of General-, Visceral, Vascular- and Pediatric Surgery, University Hospital Wuerzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany. B.von.Rahden@gmail.com
Langenbeck'S Archives of Surgery
|June 20, 2012
Summary
Colonic diverticular disease stems from diet, genetics, and aging. Complications like perforation are linked to factors such as steroid use, impacting clinical practice.
Area of Science:
- Gastroenterology
- Pathophysiology
- Colorectal Disease
Background:
- Colonic diverticular disease is a prevalent health issue in Western countries.
- Understanding its pathogenesis is crucial for effective management and prevention.
Purpose of the Study:
- To review current evidence on the pathogenesis of colonic diverticular disease and its complications.
- To synthesize information on diverticulosis, diverticulitis, complicated diverticulitis, and diverticular bleeding.
Main Methods:
- Selective Medline searches were conducted.
- Literature review focused on the formation, inflammation, and bleeding of colonic diverticula.
Main Results:
- Diverticulosis pathogenesis is multifactorial, involving diet, colonic wall changes, motility disorders, and aging.
- Diverticulitis results from microperforations, with histamine playing a role; complicated diverticulitis involves perforation and inflammatory infiltrates.
- Diverticular bleeding is a separate process caused by vas rectum rupture, often without inflammation.
Conclusions:
- The pathophysiology of diverticular disease is complex and multifactorial.
- Factors like steroid intake and immunosuppression are significant risk factors for complicated diverticulitis, with clinical implications.
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