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Updated: May 21, 2026
10:28
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Targeted therapy for gastric cancer--current status
Jan Kulig1, Piotr Kołodziejczyk, Piotr Kulig
1Department of General and Gastroenterological Surgery, Jagiellonian University Medical College, Krakow, Poland.
Summary
Trastuzumab improves survival for HER2-positive metastatic gastric cancer patients when added to chemotherapy. This targeted therapy offers a significant survival benefit without increasing adverse events, challenging previous treatment limitations.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Metastatic gastric cancer has a poor prognosis with standard chemotherapy.
- HER2 amplification/over-expression occurs in ~20% of gastric tumors, presenting a target for therapy.
- Trastuzumab is the first HER2-targeted therapy approved for gastric cancer.
Purpose of the Study:
- To evaluate the efficacy and safety of adding trastuzumab to chemotherapy in advanced gastric cancer.
- To assess the impact of HER2-targeted therapy on overall survival in gastric cancer patients.
Main Methods:
- Clinical trial evaluating trastuzumab plus chemotherapy versus chemotherapy alone.
- Assessment of overall survival and adverse events.
Main Results:
- Addition of trastuzumab to chemotherapy significantly improved overall survival.
- Trastuzumab did not increase the incidence of adverse events compared to chemotherapy alone.
Conclusions:
- Trastuzumab is an effective and safe addition to chemotherapy for HER2-positive advanced gastric cancer.
- Targeted therapy targeting HER2 offers a new treatment avenue for gastric cancer.
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