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Related Experiment Video

Updated: May 21, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Nanometer-thin solid-state nanopores by cold ion beam sculpting.

Aaron T Kuan, Jene A Golovchenko

    Applied Physics Letters
    |June 20, 2012
    PubMed
    Summary

    Researchers developed a new method called cold ion beam sculpting to create nanometer-thin solid-state nanopores. This technique enables scalable, stable, and tunable nanopore fabrication for applications like DNA sequencing.

    Area of Science:

    • Nanotechnology
    • Materials Science
    • Biophysics

    Background:

    • Protein nanopores enable single-molecule characterization, including DNA sequencing, when their constriction length is approximately one nanometer.
    • Solid-state nanopores offer superior stability and tunability compared to biological counterparts.
    • Scalable fabrication methods for nanometer-thin solid-state pores remain a challenge.

    Purpose of the Study:

    • To demonstrate a scalable method for fabricating nanometer-thin solid-state nanopores.
    • To introduce and validate "cold ion beam sculpting" as a novel technique for nanopore creation.
    • To enable advanced single-molecule analysis applications using precisely engineered solid-state nanopores.

    Main Methods:

    • Development of a novel fabrication technique termed "cold ion beam sculpting."

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    Published on: July 14, 2022

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    Last Updated: May 21, 2026

    Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
    09:43

    Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

    Published on: October 31, 2013

    Monitoring Protein Adsorption with Solid-state Nanopores
    08:51

    Monitoring Protein Adsorption with Solid-state Nanopores

    Published on: December 2, 2011

    Nanoscale Characterization of Liquid-Solid Interfaces by Coupling Cryo-Focused Ion Beam Milling with Scanning Electron Microscopy and Spectroscopy
    11:03

    Nanoscale Characterization of Liquid-Solid Interfaces by Coupling Cryo-Focused Ion Beam Milling with Scanning Electron Microscopy and Spectroscopy

    Published on: July 14, 2022

  • Application of the method to various materials for creating nanometer-scale constrictions.
  • Characterization of the fabricated solid-state nanopores for their dimensions and properties.

    • Main Results:

    • Successful fabrication of solid-state nanopores with nanometer-thin constrictions using cold ion beam sculpting.
    • Demonstration of the method's broad applicability across different materials.
    • Validation of the technique's scalability and requirement for modest instrumentation.

    Conclusions:

    • Cold ion beam sculpting is an effective and scalable method for producing nanometer-thin solid-state nanopores.
    • This technique overcomes previous limitations in fabricating solid-state nanopores for single-molecule applications.
    • The developed method holds significant potential for advancing DNA sequencing and other molecular characterization technologies.