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Updated: May 21, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Interferon in lyssavirus infection.

Martina Rieder1, Stefan Finke, Karl-Klaus Conzelmann

  • 1Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-University Munich, Munich, Germany.

Berliner Und Munchener Tierarztliche Wochenschrift
|June 21, 2012
PubMed
Summary
This summary is machine-generated.

Rabies virus and related lyssaviruses cause encephalitis. The rabies virus phosphoprotein (P) protein counters host interferon responses, potentially explaining why related viruses have a limited host range.

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Area of Science:

  • Virology
  • Immunology
  • Zoonotic Diseases

Background:

  • Rabies virus causes over 50,000 human deaths annually and is a zoonotic disease.
  • Lyssaviruses, including rabies virus, can cause rabies-like encephalitis.
  • Rabies virus infects a broad range of terrestrial animals, while related lyssaviruses primarily infect bats and rarely terrestrial species.

Purpose of the Study:

  • To investigate the factors contributing to the limited host range of rabies-related viruses.
  • To explore the role of the lyssavirus phosphoprotein (P) in evading host immune responses.

Main Methods:

  • Comparative analysis of lyssavirus phosphoprotein (P) functions.
  • Investigating viral countermeasures against the host type I interferon system.

Main Results:

  • The rabies virus P protein is crucial for inhibiting host type I interferon signaling.
  • This inhibition limits the expression of antiviral and immune-stimulating genes.

Conclusions:

  • Differential abilities of lyssavirus P proteins may determine their restricted host range.
  • Understanding these mechanisms is vital for controlling zoonotic lyssavirus infections.