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Updated: May 21, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Newer anticoagulants in critically ill patients
Anita Rajasekhar1, Rebecca Beyth, Mark A Crowther
1Department of Medicine, University of Florida, College of Medicine, Gainesville, FL 32610-0278, USA.
Critical Care Clinics
|June 21, 2012
Summary
Critically ill patients face high thrombosis risks and bleeding complications from anticoagulants. Further research is vital to understand newer anticoagulant safety and efficacy in intensive care units.
Area of Science:
- Critical care medicine
- Pharmacology
- Thrombosis research
Background:
- Critically ill patients have a higher risk of developing thrombosis.
- Thrombosis in critically ill patients is frequently underdiagnosed.
- This patient group is highly susceptible to bleeding complications when using anticoagulant therapies.
Purpose of the Study:
- To review the pharmacology of anticoagulants in critically ill patients.
- To examine clinical trial data on anticoagulant use in intensive care units (ICUs).
- To discuss the management of bleeding complications and perioperative use of anticoagulants in the ICU population.
Main Methods:
- Literature review of pharmacology.
- Analysis of clinical trial data.
- Review of management strategies for bleeding complications and perioperative use.
Main Results:
- Anticoagulants are essential for managing thrombosis in critically ill patients.
- The use of newer anticoagulant agents presents unique challenges regarding safety and efficacy in the ICU.
- Bleeding complications and perioperative management require careful consideration.
Conclusions:
- Current understanding of newer anticoagulants in critically ill patients is limited.
- Well-designed clinical trials are necessary to establish optimal safety and efficacy profiles.
- Improved evidence is needed to guide anticoagulant therapy in the intensive care setting.
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