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Updated: May 21, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
[Possible aggravation of a Henoch Schoenlein purpura by isotretinoin]
A Derungs1, K Eberhardt, U Heiniger
1Abteilung für Klinische Pharmakologie und Toxikologie, Regionales Pharmacovigilance-Zentrum Basel, Universitätsspital Basel, Basel.
Abstract:
We report on a 16 year old patient with a hemorrhagic bullous form of a Henoch-Schönlein purpura. The cause for the event could not be determined, but the patient recovered without complications. Since he had begun a therapy with isotretinoin due to an acne inversa 3 weeks before, a possible association between the event and the treatment could not be excluded, and the case was reported to Swissmedic. In the comment, we discuss the pharmacology of isotretinoin, drug-induced vasculitis, and its pathomechanisms. As a general reminder, the criteria for the causality assessment of adverse drug reactions as well as the reporting system of adverse drug reactions in Switzerland are discussed.
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