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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

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Related Experiment Video

Updated: May 21, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

[Vitamin D in aortic stenosis].

Katerina Linhartová1, G Stěrbáková, R Cerbák

  • 1Kardiologická klinika 2. lékarské fakulty UK a FN Motol Praha. linhartkaterina@seznam.cz

Vnitrni Lekarstvi
|June 22, 2012
PubMed
Summary

Aortic stenosis, a common heart valve disease, may be linked to calcium and phosphate imbalances, even with healthy kidneys. Further research is needed to explore vitamin D

Area of Science:

  • Cardiology
  • Biochemistry
  • Pathophysiology

Context:

  • Aortic stenosis is a prevalent cardiovascular disease and the most frequent reason for valve surgery in developed nations.
  • Progressive calcification of the aortic valve leads to significant obstruction of blood flow, representing its primary pathogenetic feature.

Purpose:

  • To investigate the potential role of systemic calcium-phosphate metabolism dysregulation and low vitamin D levels as risk factors for aortic stenosis.
  • To explore these factors even in patients with preserved renal function.

Summary:

  • Aortic stenosis, a leading cause of cardiovascular disease and valve surgery, is characterized by progressive valve calcification.
  • Dysregulation in calcium-phosphate metabolism and low vitamin D levels are hypothesized as potential contributors to aortic stenosis.

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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

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Related Experiment Videos

Last Updated: May 21, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Published on: March 31, 2023

  • This association is proposed to exist independently of renal function status.

    • Impact:

    • Highlights a potential modifiable risk factor for aortic stenosis.
    • Suggests new avenues for clinical and experimental research into aortic stenosis pathogenesis.
    • May inform future preventative strategies for cardiovascular health.