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Updated: May 21, 2026
08:40
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
miRcode: a map of putative microRNA target sites in the long non-coding transcriptome
Ashwini Jeggari1, Debora S Marks, Erik Larsson
1Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
Bioinformatics (Oxford, England)
|June 22, 2012
Summary
Long non-coding RNAs (lncRNAs) are emerging regulators of cell physiology, with functions still being explored. miRcode is a new tool mapping microRNA-lncRNA interactions to advance research in this area.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators of cellular processes.
- Their interactions with small non-coding RNAs, like microRNAs (miRNAs), are significant but understudied.
- lncRNAs can function as miRNA decoys or targets, influencing gene expression.
Purpose of the Study:
- To create a comprehensive resource for studying microRNA-lncRNA interactions.
- To facilitate the exploration of the regulatory roles of lncRNAs.
Main Methods:
- Development of miRcode, a searchable database.
- Mapping of putative microRNA target sites across the human transcriptome.
- Inclusion of 10,419 lncRNA genes in the current version.
Main Results:
- miRcode provides a comprehensive map of potential miRNA binding sites on lncRNAs.
- The database covers the complete GENCODE annotated transcriptome.
- It includes a substantial number of annotated lncRNA genes.
Conclusions:
- miRcode serves as a valuable tool for investigating the functional interplay between miRNAs and lncRNAs.
- This resource will aid in understanding the diverse regulatory roles of lncRNAs in cell physiology.
- Further exploration of miRNA-lncRNA interactions is warranted.
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