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Updated: May 21, 2026
12:02
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
N-Hexyl-3-(4-hy-droxy-3,5-dimeth-oxy-phen-yl)propanamide.
Summary
This study details the crystal structure of a lipophilic hydro-sinapic acid derivative. Molecular analysis reveals unique bond lengths and angles, with intermolecular hydrogen bonding forming 2D networks and chains.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Hydro-sinapic acid derivatives are explored for their potential applications.
- Increased lipophilicity can be achieved through alkyl chain modifications.
- Understanding molecular structure is crucial for predicting material properties.
Purpose of the Study:
- To elucidate the crystal structure of a novel hydro-sinapic acid derivative.
- To analyze the molecular geometry, including bond lengths and angles.
- To investigate intermolecular interactions and their role in crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular structure.
- Analysis of bond lengths, bond angles, and torsional angles was performed.
- Intermolecular interactions, such as hydrogen bonding, were identified and characterized.
Main Results:
- The title compound, a hydro-sinapic acid derivative with an added alkyl chain, exhibits distinct molecular geometry.
- Shorter C-N and C-C bond lengths were observed in the linear chains compared to average values.
- The molecule displays specific dihedral angles between the phenyl ring, central plane, and hexyl chain.
- A two-dimensional network is formed via bifurcated hydrogen bonds involving the amide N-H group.
- The hydroxyl group participates in hydrogen bonding, leading to chain formation along the b axis.
Conclusions:
- The crystal structure reveals a unique arrangement of a lipophilic hydro-sinapic acid derivative.
- The observed bond lengths and molecular conformation are influenced by the alkyl chain.
- Intermolecular hydrogen bonding plays a significant role in the self-assembly and crystal architecture.
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