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Updated: May 21, 2026
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
(E)-N'-(3-Fluoro-benzyl-idene)-4-methyl-benzohydrazide
1College of Chemistry and Pharmacy, Taizhou University, Taizhou Zhejiang 317000, People's Republic of China.
Summary
This study details the crystal structure of a fluorinated organic compound, C(15)H(13)FN(2)O. Molecular analysis reveals specific dihedral angles and hydrogen bonding patterns influencing its solid-state arrangement.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Understanding the solid-state structure of organic molecules is crucial for predicting their physical and chemical properties.
- Fluorinated organic compounds exhibit unique electronic and structural characteristics.
- Hydrogen bonding plays a significant role in molecular self-assembly and crystal engineering.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(15)H(13)FN(2)O.
- To analyze the molecular conformation, including dihedral angles between aromatic rings.
- To investigate intermolecular interactions, specifically hydrogen bonding, in the crystalline state.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the three-dimensional molecular structure.
- Analysis of crystallographic data provided precise measurements of bond lengths, bond angles, and dihedral angles.
- Intermolecular interactions were identified and characterized using hydrogen bond analysis.
Main Results:
- The crystal structure of C(15)H(13)FN(2)O was successfully determined.
- A dihedral angle of 16.9(2)° was observed between the two benzene rings.
- The fluorine and oxygen atoms were found to be in a syn conformation.
- Molecules were observed to form C(4) chains via N-H⋯O hydrogen bonds along the b-axis.
Conclusions:
- The study provides a detailed structural characterization of the title compound.
- The observed dihedral angle and syn conformation offer insights into the molecule's preferred spatial arrangement.
- The identified hydrogen bonding network highlights the self-assembly behavior in the crystal lattice.
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