(1S,5R,7R,30S)-14-De-oxy-isogarcinol

Area of Science:

• Natural Product Chemistry
• Organic Chemistry
• Structural Biology

Background:

• Garcinia indica fruits are a source of bioactive compounds.
• Polyisoprenylated benzophenones are a class of natural products with potential bioactivity.
• Previous research has identified compounds like isogarcinol from Garcinia species.

Purpose of the Study:

• To isolate and characterize a novel polyisoprenylated benzophenone from Garcinia indica.
• To determine the relative configuration of the newly isolated compound.
• To compare its crystal structure with known isomorphous and isostructural compounds.

Main Methods:

• Large-scale extraction of bioactive compounds from Garcinia indica fruits.
• Spectroscopic analysis (NMR, MS) for structural elucidation.
• X-ray crystallography for crystal structure determination and comparison.
• Optical rotation measurements.

Main Results:

• Isolation and identification of a new polyisoprenylated benzophenone (C(38)H(50)O(5)).
• Determination of the relative configuration by comparing spectroscopic and optical rotation data with isogarcinol.
• Confirmation of isomorphous and isostructural relationship with isogarcinol through crystal packing analysis.

Conclusions:

• A new polyisoprenylated benzophenone has been discovered in Garcinia indica.
• The compound shares structural and crystallographic similarities with isogarcinol.
• This finding contributes to the understanding of Garcinia-derived natural products.