Related Experiment Video
Updated: May 21, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
Published on: November 22, 2014
Methyl 3-amino-but-2-enoate
1Department of Applied Chemistry, Harbin Institute of Technology, Harbin, Heilongjiang 150001, People's Republic of China.
Abstract:
The title compound, C(5)H(9)NO(2), is almost planar (r.m.s. deviation for the non-H atoms = 0.036 Å) and an intra-molecular N-H⋯O hydrogen bond generates an S(6) ring. In the crystal, N-H⋯O inter-actions link the mol-ecules into C(6) chains propagating along [010].
Related Concept Videos
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Conjugate Addition of Enolates: Michael Addition
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis

