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10:41
A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
Published on: April 30, 2020
Implementing the global plan to stop TB, 2011-2015--optimizing allocations and the Global Fund's contribution: a
Eline L Korenromp1, Philippe Glaziou, Christopher Fitzpatrick
1Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland. eline.korenromp@theglobalfund.org
Plos One
|June 22, 2012
Summary
Optimizing Global Fund investments for tuberculosis (TB) control could save 37% more lives. Prioritizing TB/HIV treatment in Africa offers the highest impact for TB funding.
Area of Science:
- Global health economics
- Infectious disease control
- Public health policy
Background:
- The Global Plan to Stop TB outlines funding needs for TB control in low- and middle-income countries.
- Estimates Global Fund investment impact across interventions and regions.
Purpose of the Study:
- To estimate the cost and mortality impact of TB diagnosis and treatment, including drug-resistant TB and HIV co-infection.
- To analyze Global Fund investment scenarios for optimal allocation.
Main Methods:
- Utilized Global Plan assumptions for cases and mortality.
- Estimated treatment costs and mortality impact for drug-sensitive and multidrug-resistant TB (MDR-TB).
- Modeled Global Fund contributions under various allocation scenarios.
Main Results:
- In 2015, funding needs varied by region: China/India (24%), Eastern Europe/Central Asia (EECA) (33%), Sub-Saharan Africa (SSA) (20%), and others (24%).
- MDR-TB treatment scale-up, particularly in EECA, drives global funding needs.
- SSA shows the fastest rise in funding needs due to TB/HIV management.
- Global Fund expected to finance 8-12% of costs annually.
- Shifting allocations to prioritize TB/HIV treatment and DOTS in Africa could increase lives saved by 37%.
Conclusions:
- Findings should inform international donors and national governments on optimal investment strategies.
- Focusing on highest-impact populations and interventions is crucial for TB control.
- Country funding gaps, domestic resources, and implementation capacity are key considerations.
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