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Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapy

Pascale Hubert1, Sebastian Amigorena

  • 1Institut Curie; Centre de Recherche; Paris, France ; INSERM; U93; Paris, France.

Oncoimmunology
|June 22, 2012
PubMed

Antibody-dependent cell cytotoxicity (ADCC) is critical in monoclonal antibody (mAb)-mediated cancer therapy. We recently showed that a tumor-specific mAb in combination with cyclophosphamide inhibited tumor cell growth and induced ADCC-synapses between tumor and effector cells in vivo, opening perspectives to enhance anti-tumor responses by manipulating the immune system.

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