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STAT3 inhibition for the induction of immunogenic cell death in multiple myeloma

Oliver Kepp1,2, Guido Kroemer1,2,3

  • 1INSERM US23 AMMICa, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.

Oncoimmunology
|September 15, 2026
PubMed

Keywords:
Immunotherapycalreticulinintegrated stress responsenapabucasin

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.