CCR5 in cancer immunotherapy: More than an "attractive" receptor for T cells
Alicia González-Martín1, Emilia Mira, Santos Mañes
1Department of Immunology and Oncology; Centro Nacional de Biotecnología CNB/CSIC; Darwin 3; Campus Cantoblanco; Madrid, Spain.
Oncoimmunology
|June 22, 2012
Abstract:
Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5 expression by both CD4+ and CD8+ T cells is necessary to boost anti-tumor responses by optimizing helper-dependent CD8+ T cell priming. Our findings could have implications for cancer treatment in patients with defective CCR5 expression.
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