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Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow

Alessandro Poggi1, Maria Raffaella Zocchi

  • 1Unit of Molecular Oncology and Angiogenesis; San Martino Hospital-National Institute for Cancer Research; University of Genoa; Genoa, Italy.

Oncoimmunology
|June 22, 2012
PubMed

We discuss our recent findings on the increase, in chronic myeloid leukemia patients treated with imatinib, of B1 lymphocytes producing IgM anti-O-linked sugars expressed by leukemic cells, paralleled by increased B-stimulating cytokines. We propose that one important effect of imatinib treatment is due to the remodelling of bone marrow microenvironment.

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