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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

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Related Experiment Video

Updated: May 21, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

[Spasticity and everyday life in multiple sclerosis].

C Donzé1, J De Sèze

  • 1Service de Médecine Physique et Réadaptation Fonctionnelle, Hôpital Saint-Philibert, Rue du Grand But, BP 249-59462 Lomme cedex, France. donze.cecile@ghicl.net

Revue Neurologique
|June 23, 2012
PubMed
Summary

Spasticity significantly impacts daily life and mobility in multiple sclerosis patients. Current assessments overlook its effect on activities of daily living and quality of life.

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Related Experiment Videos

Last Updated: May 21, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Area of Science:

  • Neurology
  • Rehabilitation Medicine

Context:

  • Spasticity is a prevalent symptom in multiple sclerosis (MS).
  • Existing clinical scales for spasticity often fail to capture its real-world impact on patients' lives.
  • Daily activities like mobility, walking, household chores, and personal care are frequently affected.

Purpose:

  • To highlight the unmet need for assessing spasticity's impact on daily life in MS patients.
  • To emphasize the importance of understanding how spasticity affects activities of daily living (ADL) and quality of life (QoL).

Summary:

  • Spasticity profoundly affects multiple sclerosis patients' daily functioning and mobility.
  • Current evaluation methods do not adequately measure the functional limitations imposed by spasticity.
  • No prior studies have comprehensively described the impact of spasticity on the everyday lives of individuals with MS.

Impact:

  • This research underscores the necessity of developing new assessment tools.
  • Understanding spasticity's effect on ADL is crucial for tailoring effective therapeutic interventions.
  • Addressing these impacts is vital for improving the quality of life for the MS population.