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Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
06:31

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Published on: November 27, 2015

Diastereoselective chelation-controlled additions to β-silyloxy aldehydes

Gretchen R Stanton1, Meara C Kauffman, Patrick J Walsh

  • 1P. Roy and Diana T. Vagelos Laboratories, University of Pennsylvania, Department of Chemistry, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.

Organic Letters
|June 23, 2012
PubMed
Summary

This study introduces a new diastereoselective method for adding organozinc reagents to aldehydes. The developed technique efficiently controls stereochemistry, yielding highly diastereoselective products for organic synthesis applications.

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