Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"White seborrheic keratosis": a misunderstood entity in skin of color.

Annales de dermatologie et de venereologie·2026
Same author

Erythrosis pigmentosa mediofacialis (Brocq): A hypothesis on the involvement of Demodex folliculorum.

Annales de dermatologie et de venereologie·2025
Same author

Strong propensity to accept a diagnosis via tele-expertise in dermatology: A nationwide analysis.

Annales de dermatologie et de venereologie·2025
Same author

Two cases of bullous haemorrhagic dermatosis (BHD) induced by enoxaparin.

Annales de dermatologie et de venereologie·2024
Same author

Treatment of facial and axillary lupus miliaris with adalimumab.

Annales de dermatologie et de venereologie·2024
Same author

Non-scarring alopecia of lupus erythematosus: A comprehensive review.

Annales de dermatologie et de venereologie·2023
Same journal

2024 guidelines (S3) for the therapeutic management of patients with genital herpes.

Annales de dermatologie et de venereologie·2026
Same journal

Topical JAK inhibitors in the lichen planus spectrum: a systematic review.

Annales de dermatologie et de venereologie·2026
Same journal

2024 recommendations for the therapeutic management of anogenital warts.

Annales de dermatologie et de venereologie·2026
Same journal

Successful use of thalidomide in treating metastatic Crohn's disease.

Annales de dermatologie et de venereologie·2026
Same journal

Multiple cutaneous juvenile xanthogranuloma: a monocentric study.

Annales de dermatologie et de venereologie·2026
Same journal

Cartilage-hair-hypoplasia associated with granulomatosis induced by rubella vaccine.

Annales de dermatologie et de venereologie·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Picrosirius Red Staining for Semiquantitative Histopathologic Evaluation of Collagen Deposition in Murine Models of Chronic Lung Allograft Rejection
04:42

Picrosirius Red Staining for Semiquantitative Histopathologic Evaluation of Collagen Deposition in Murine Models of Chronic Lung Allograft Rejection

Published on: March 21, 2025

[Reactive perforating collagenosis].

A Salhi1, E Heid, E Grosshans

  • 1Service de dermatologie, hôpital central de l'Armée Ain Naadja (HCA), Kouba 16000 Alger, Algérie. salhi 2002dz@yahoo.fr

Annales De Dermatologie Et De Venereologie
|June 23, 2012
PubMed
Summary
This summary is machine-generated.

Hereditary reactive perforating collagenosis (RPC) is a rare condition. This case study highlights a familial diagnosis in siblings, suggesting a genetic basis for this rare perforating dermatosis.

More Related Videos

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury
07:46

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury

Published on: June 29, 2015

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Experiment Videos

Last Updated: May 21, 2026

Picrosirius Red Staining for Semiquantitative Histopathologic Evaluation of Collagen Deposition in Murine Models of Chronic Lung Allograft Rejection
04:42

Picrosirius Red Staining for Semiquantitative Histopathologic Evaluation of Collagen Deposition in Murine Models of Chronic Lung Allograft Rejection

Published on: March 21, 2025

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury
07:46

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury

Published on: June 29, 2015

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Reactive perforating collagenosis (RPC) is a rare perforating dermatosis.
  • Two types exist: hereditary and acquired, with the latter associated with systemic diseases.
  • Hereditary RPC typically manifests in early childhood.

Observation:

  • A young man presented with crusted papular lesions on his hands since childhood.
  • Histologic analysis revealed characteristic epidermal changes with extruded collagen.
  • The patient's brother had similar lesions, supporting a hereditary diagnosis.

Findings:

  • The case presented is consistent with hereditary reactive perforating collagenosis.
  • The familial occurrence strongly suggests a genetic etiology.
  • Superficial trauma is a suspected, though unproven, trigger for hereditary RPC.

Implications:

  • This case reinforces the recognition of hereditary RPC as a distinct entity.
  • Further research into the pathogenesis of hereditary RPC is warranted.
  • Understanding the genetic basis may lead to targeted therapies for this rare dermatosis.