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Updated: May 21, 2026
08:41
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
[Vasoreactivity changes during extracorporeal circulation: effects of halogenated agents]
H Lanquetot1, J-M Charrière, L Soubiron
1Département d'anesthésie-réanimation, Centre Hospitalier Universitaire de Poitiers, 2 rue de Milèterie, 8602 Poitiers cedex, France. herve.lanquetot@chu- poitiers.fr
Annales Francaises D'Anesthesie Et De Reanimation
|June 23, 2012
Summary
This study examines how anesthetic agents affect vascular tone during cardiopulmonary bypass (CPB). Isoflurane administration during CPB did not show deleterious effects on vascular systemic resistance (VSR), suggesting potential safety in normothermic conditions.
Area of Science:
- Anesthesiology
- Cardiovascular Surgery
- Vascular Physiology
Background:
- Cardiopulmonary bypass (CPB) can disrupt endothelial function, altering vasomotor tone and vascular systemic resistance (VSR).
- Halogenated anesthetic agents administered during CPB can influence vascular tone, typically decreasing VSR under hypothermic conditions.
Purpose of the Study:
- To summarize the impact of endothelial function on vascular tone during CPB.
- To report the physiological and clinical effects of halogenated agents and CPB on vasomotor tone.
- To investigate the clinical experience of isoflurane administration during CPB regarding VSR and vasoplegia.
Main Methods:
- Bibliographic review of endothelial function, halogenated agents, and CPB.
- Retrospective analysis of over 4000 patients receiving isoflurane during CPB.
- Identification of factors predicting severe vasoplegia.
Main Results:
- Halogenated agents generally decrease VSR above one Minimum Alveolar Concentration (MAC) during hypothermic bypass.
- A 9.5% incidence of severe vasoplegia was observed in the isoflurane group, consistent with previous findings.
- Predictors of vasoplegia included preoperative Euroscore, hemodynamic instability, surgical complexity, and CPB duration.
Conclusions:
- Isoflurane administration during normothermic CPB did not appear to cause deleterious effects on VSR.
- Further prospective comparative studies are needed to confirm the safety and efficacy of isoflurane versus other anesthetic agents during CPB.
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