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Updated: May 21, 2026
07:09
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Signalling. A new role for MYC?
1NCI-Nature Pathway Interaction Database.
Nature Reviews. Cancer
|June 23, 2012
Abstract:
Liu et al. have identified MYC as a suppressor of metastasis, cell motility and invasion, and provide evidence that this newly uncovered role is dependent on the αv and β3 integrin extracellular matrix receptors.
Insights
The MYC gene suppresses cancer metastasis and cell movement. This function relies on specific cell surface receptors, namely alpha-v and beta-3 integrins.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- The MYC oncogene is a well-established driver of cell proliferation and growth.
- Its role in regulating cell motility, invasion, and metastasis has been less understood.
Discussion:
- This study reveals a novel function of MYC as a suppressor of metastasis, cell motility, and invasion.
- This newly identified role is mechanistically linked to the activity of alpha-v (αv) and beta-3 (β3) integrin receptors.
Key Insights:
- MYC acts as a suppressor of cancer cell metastasis and invasion.
- The metastatic suppressor activity of MYC is dependent on its interaction with αvβ3 integrin.
Outlook:
- Further investigation into the MYC-integrin axis could reveal new therapeutic targets for preventing cancer spread.
- Understanding this pathway may lead to novel strategies for inhibiting tumor metastasis.
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