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Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
Published on: November 17, 2015
Lipid-based carriers: manufacturing and applications for pulmonary route
Chiraz Jaafar-Maalej1, Abdelhamid Elaissari, Hatem Fessi
1Université Lyon 1, Laboratoire d'Automatique et de Génie des Procédés, UMR 5007, CNRS, CPE, 43 bd du 11 Novembre, 69622 Villeurbanne Cedex, France.
Expert Opinion on Drug Delivery
|June 26, 2012
Summary
Lipid-based carriers (LBCs), including liposomes and solid lipid nanoparticles (SLNs), show promise for pulmonary drug delivery. However, challenges related to the respiratory tract and toxicity assessments hinder their widespread clinical application.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Recent advances in aerosol therapy drive interest in novel pulmonary drug delivery systems.
- Encapsulating bioactive molecules into lipid-based carriers (LBCs) like liposomes and solid lipid nanoparticles (SLNs) improves therapeutic index and reduces side effects.
- LBCs represent a significant area of growth in pharmaceutical drug delivery.
Purpose of the Study:
- To review lipid-based colloidal carriers (liposomes and SLNs) for pulmonary drug delivery.
- To discuss conventional and novel methods for liposome preparation and SLN manufacturing.
- To summarize recent research and address toxicological concerns of pulmonary lipidic carriers.
Main Methods:
- Literature review of lipid-based colloidal carriers for pulmonary delivery.
- Discussion of liposome preparation techniques.
- Analysis of SLN manufacturing methods.
- Summary of recent publications and results.
- Brief consideration of toxicological aspects.
Main Results:
- Liposomes and SLNs are key LBCs for pulmonary drug delivery.
- Various methods exist for preparing liposomes and manufacturing SLNs.
- Recent research highlights progress in pulmonary lipidic carriers.
- Toxicological considerations are important for these systems.
Conclusions:
- Despite advantages, LBCs for pulmonary delivery face challenges.
- The complexity of the respiratory tract limits LBC application.
- Lack of comprehensive toxicity assessment poses a significant hurdle for clinical use.
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