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Updated: May 21, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Gluten-dependent intestinal autoimmune response
Ilma Rita Korponay-Szabó1, Zsafia Simon-Vecsei, Luigina De Leo
1Department of Pediatrics, University of Debrecen, Nagyerdei krt 98, H-4012 Debrecen, Hungary. ilma.korponay-szabo@uta.fi
Current Pharmaceutical Design
|June 26, 2012
Summary
Celiac disease involves gluten triggering autoimmune responses in genetically susceptible individuals. Anti-transglutaminase antibodies play a key role in the disease
Area of Science:
- Immunology
- Gastroenterology
- Autoimmune Diseases
Background:
- Celiac disease is an autoimmune disorder affecting the small intestine, triggered by gluten ingestion in genetically susceptible individuals.
- The condition is characterized by the production of auto-antibodies, particularly anti-transglutaminase antibodies, within the intestinal mucosa.
- These antibodies, along with gliadin-specific T lymphocytes, are implicated in the disease's pathogenesis.
Purpose of the Study:
- To review the effects of anti-transglutaminase antibodies.
- To discuss the role of these antibodies in the pathogenesis of various celiac disease manifestations.
Main Methods:
- Literature review focusing on anti-transglutaminase antibodies.
- Analysis of their contribution to celiac disease pathogenesis.
Main Results:
- Anti-transglutaminase antibodies are specifically and gluten-dependently produced in the intestinal mucosa.
- These antibodies deposit in both intestinal and extra-intestinal tissues.
- Their biological effects, alongside T lymphocytes, contribute to celiac disease pathology.
Conclusions:
- Anti-transglutaminase antibodies are central players in the pathogenesis of celiac disease.
- Understanding their effects is crucial for comprehending the multi-systemic manifestations of the disease.
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