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Tobacco smoking and aortic aneurysm: two population-based studies
Birgitte F Sode1, Børge G Nordestgaard, Morten Grønbæk
1Dept of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Rigshospitalet, Denmark.
International Journal of Cardiology
|June 26, 2012
Summary
Tobacco smoking is the leading risk factor for aortic aneurysm, significantly increasing hospitalization and death. This finding highlights the critical role of smoking cessation in preventing aortic aneurysm outcomes.
Area of Science:
- Cardiovascular epidemiology
- Public health research
- Risk factor analysis
Background:
- Investigating the predictive power of tobacco smoking on aortic aneurysm development.
- Comparing smoking's impact against other risk factors in the general population.
Purpose of the Study:
- To determine the predictive power of tobacco smoking on aortic aneurysm.
- To compare tobacco smoking with other risk factors for aortic aneurysm.
Main Methods:
- Analysis of 15,072 individuals from the Copenhagen City Heart Study (up to 34 years follow-up).
- Analysis of 56,211 individuals from the Copenhagen General Population Study (up to 7 years follow-up).
- Recording tobacco smoking and other risk factors at baseline; assessing aortic aneurysm hospitalization and death.
Main Results:
- Tobacco consumption identified as the most significant risk factor for aortic aneurysm outcomes.
- Population attributable risk for aortic aneurysm due to tobacco consumption was 64% and 47% in the respective cohorts.
- Absolute 10-year risk for aortic aneurysm outcomes was higher in males and individuals with specific risk profiles.
Conclusions:
- Tobacco smoking is the primary predictor of future aortic aneurysm outcomes.
- Population attributable risks for aortic aneurysm associated with smoking exceed 47%.
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