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Nonfasting Triglycerides, Low-Density Lipoprotein Cholesterol, and Heart Failure Risk: Two Cohort Studies of 113 554
Anette Varbo1, Børge G Nordestgaard2
1From the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark (A.V.); The Copenhagen General Population Study (A.V., B.G.N.) and Department of Clinical Biochemistry, Herlev and Gentofte Hospital (A.V., B.G.N.), Copenhagen University Hospital, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B.G.N.); and The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Denmark (B.G.N.).
Arteriosclerosis, Thrombosis, and Vascular Biology
|November 4, 2017
Summary
High nonfasting triglycerides increase heart failure risk in the general population. Low-density lipoprotein cholesterol levels did not show an association with heart failure risk.
Area of Science:
- Cardiology
- Epidemiology
- Metabolic Syndrome
Background:
- Heart failure (HF) prevalence is rising, particularly in aging populations, leading to significant morbidity and mortality.
- Identifying modifiable risk factors is crucial for effective HF prevention strategies.
Purpose of the Study:
- To investigate the association between nonfasting triglyceride and low-density lipoprotein cholesterol concentrations and the risk of developing heart failure in the general population.
Main Methods:
- Two prospective observational studies (Copenhagen General Population Study and Copenhagen City Heart Study) involving over 113,000 individuals.
- Measurement of nonfasting triglycerides and LDL cholesterol at baseline, with follow-up for up to 23 years.
- Analysis using Cox proportional hazard regression models to estimate hazard ratios for heart failure diagnosis.
Main Results:
- Stepwise increases in nonfasting triglyceride concentrations were significantly associated with a stepwise increase in heart failure risk.
- Individuals with nonfasting triglycerides ≥5 mmol/L had a 2.59-fold higher risk of heart failure compared to those with <1 mmol/L.
- Low-density lipoprotein cholesterol concentrations showed no significant association with heart failure risk.
Conclusions:
- Elevated nonfasting triglyceride levels are a significant, modifiable risk factor for heart failure in the general population.
- Low-density lipoprotein cholesterol is not associated with heart failure risk based on this study.
- Findings support targeting nonfasting triglyceride management for heart failure prevention.
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