Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 21, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Correlation between maternal inflammatory markers and fetomaternal adiposity.

Nadine Farah1, Andrew E Hogan, Norah O'Connor

  • 1UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin 8, Ireland. drnfarah@gmail.com

Cytokine
|June 26, 2012
PubMed
Summary

Maternal inflammatory cytokines in the third trimester are linked to a mother's own body fat, but not the baby's size. This study excluded gestational diabetes mellitus (GDM) to clarify these relationships.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental regulation of mucosal-associated invariant T cells: Adding food for thought.

Science signaling·2026
Same author

Epidemiology of Obesity During Pregnancy in Europe: A Systematic Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation.

EMBO reports·2026
Same author

Interventions to prevent antipsychotic-induced weight gain and metabolic complications in individuals with a first-episode psychosis and minimal antipsychotic exposure: a systematic review and meta-analysis.

Psychological medicine·2026
Same author

Evaluating the impact of GLP-1 receptor agonists in combination with total neoadjuvant therapy for locally advanced rectal cancer.

The British journal of surgery·2026

Area of Science:

  • Reproductive biology
  • Immunology
  • Metabolic disorders

Background:

  • Obesity and diabetes mellitus are known to alter inflammatory cytokine profiles outside of pregnancy.
  • Obesity during pregnancy can lead to complications like gestational diabetes mellitus (GDM) and fetal macrosomia.
  • Understanding the interplay between maternal adiposity, cytokines, and fetal outcomes is crucial, especially when excluding GDM.

Purpose of the Study:

  • To investigate the correlation between maternal cytokines and fetomaternal adiposity in the third trimester.
  • To specifically exclude gestational diabetes mellitus (GDM) as a confounding variable.
  • To differentiate associations with maternal adiposity versus fetal adiposity.

Main Methods:

  • Enrolled healthy pregnant women with singleton pregnancies and normal glucose tolerance tests at 28 weeks gestation.

More Related Videos

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

Related Experiment Videos

Last Updated: May 21, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

  • Measured maternal cytokines at 28 and 37 weeks gestation.
  • Assessed maternal adiposity via Body Mass Index (BMI) and bioelectrical impedance analysis; assessed fetal adiposity via ultrasound and birthweight.

    • Main Results:

    • Of 71 women, 45% were obese (mean BMI 29.2 kg/m²).
    • Maternal Interleukin-6 (IL-6) and Interleukin-8 (IL-8) levels correlated with maternal adiposity.
    • No correlation was found between maternal Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1 beta (IL-1β), IL-6, IL-8 levels and fetal adiposity or birthweight.

    Conclusions:

    • In non-diabetic pregnant women, circulating maternal cytokines are associated with maternal adiposity in the third trimester.
    • These maternal cytokine levels do not appear to be associated with fetal adiposity or birthweight in this cohort.
    • Findings suggest maternal inflammatory markers are linked to maternal metabolic status rather than directly influencing fetal growth in the absence of GDM.