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Diffuse tubulointerstitial nephritis accompanied by renal crystal formation in an HIV-infected patient undergoing
Go Kanzaki1, Nobuo Tsuboi, Yoichi Miyazaki
1Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan. g-kanzaki@jikei.ac.jp
Abstract:
This report presents a human immunodeficiency virus (HIV) patient that developed a slowly progressive renal impairment over years under highly active antiretroviral therapy (HAART). The renal biopsy showed diffuse tubulointerstitial nephritis accompanied by crystal formations that were surrounded by multinuclear giant cells. Furthermore, rod-like crystals were detected in the urinary sediments. Tenofovir and Atazanavir were thought to be the causative drugs for the renal injury. Therefore, the possibility of HARRT-induced nephrotoxicity should be considered in HIV-infected patients, even though the activity of HIV is controlled by such therapies.
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