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Effect of probiotics on allergic rhinitis in Df, Dp or dust-sensitive children: a randomized double blind controlled
Teng-Yi Lin1, Chia-Jung Chen, Li-Kuang Chen
1Department of Laboratory Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Insights
Lactobacillus salivarius supplementation effectively reduced allergic rhinitis symptoms and medication use in children. This probiotic intervention showed significant clinical benefits without altering immunological markers.
Area of Science:
- Immunology
- Microbiology
- Pediatrics
Background:
- Allergic rhinitis (AR) significantly impacts children's quality of life.
- Current treatments for AR may have limitations or side effects.
- Probiotics, like Lactobacillus salivarius, are being explored for immune modulation.
Purpose of the Study:
- To investigate the efficacy of Lactobacillus salivarius in managing allergic rhinitis symptoms in children.
- To assess the impact of Lactobacillus salivarius on medication requirements for allergic rhinitis.
Main Methods:
- A double-blind, randomized, controlled trial was conducted.
- Children with allergic rhinitis received daily Lactobacillus salivarius or a placebo for 12 weeks.
- Rhinitis symptom and medication scores were assessed regularly, alongside immunological and blood cell counts.
Main Results:
- Lactobacillus salivarius treatment led to a significant reduction in rhinitis symptoms.
- A notable decrease in medication scores was observed in the probiotic group.
- No significant differences in immunological or blood cell variables were found between groups.
Conclusions:
- Lactobacillus salivarius is a promising therapeutic option for reducing allergic rhinitis symptoms in children.
- This probiotic may decrease the need for medication in pediatric allergic rhinitis.
- Further research could explore mechanisms and long-term effects.
Objective:
To study, we examined the effect of Lactobacillus salivarius on the clinical symptoms and medication use among children with established allergic rhinitis (AR).
Design:
Double blind, randomized, controlled trial.
Setting:
Hualien Tzu-Chi General Hospital.
Methods:
Atopic children with current allergic rhinitis received 4x10(9) colony forming units/g of Lactobacillus salivarius (n=99) or placebo (n=100) daily as a powder mixed with food or water for 12 weeks. The SCORing Allergic rhinitis index (specific symptoms scores [SSS] and symptom medication scores [SMS]), which measures the extent and severity of AR, was assessed in each subject at each of the visits--2 weeks prior to treatment initiation (visit 0), at the beginning of the treatment (visit 1), then at 4 (visit 2), 8 (visit 3) and 12 weeks (visit 4) after starting treatment. The WBC, RBC, platelet and, eosinophil counts as well as the IgE antibody levels of the individuals were evaluated before and after 3 months of treatment.
Results:
The major outcome, indicating the efficacy of Lactobacillus salivarius treatment, was the reduction in rhinitis symptoms and drug scores. No significant statistical differences were found between baseline or 12 weeks in the probiotic and placebo groups for any immunological or blood cell variables.
Conclusions:
Our study demonstrates that Lactobacillus salivarius treatment reduces rhinitis symptoms and drug usage in children with allergic rhinitis.
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