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Vitamin K-dependent multifactor coagulopathy in Devon Rex cats.

J E Maddison1, A D Watson, I G Eade

  • 1Department of Veterinary Clinical Sciences, University of Sydney, N.S.W., Australia.

Journal of the American Veterinary Medical Association
|December 1, 1990
PubMed
Summary

Three Devon Rex cats experienced vitamin K deficiency, impacting blood clotting factors. Oral vitamin K1 treatment normalized levels, but deficiency recurred upon discontinuation, even without bleeding symptoms.

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Area of Science:

  • Veterinary Medicine
  • Hematology
  • Nutritional Science

Background:

  • Coagulopathy can arise from vitamin K deficiency, affecting crucial clotting factors (II, VII, IX, X).
  • Devon Rex cats are a specific breed focus for this hematological study.

Observation:

  • Three Devon Rex cats presented with coagulopathy due to vitamin K-dependent clotting factor deficiency.
  • No rodenticide exposure, hepatic disease, gastrointestinal issues, or fat malassimilation were identified as causes.
  • Oral vitamin K1 supplementation successfully normalized clotting factor concentrations in affected cats.

Findings:

  • Vitamin K1 treatment effectively reversed the coagulopathy in Devon Rex cats.
  • Discontinuation of vitamin K1 led to the recurrence of prolonged clotting times in two cats.

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  • Recurrence of prolonged clotting times occurred without overt clinical signs of a bleeding disorder.

    • Implications:

    • This suggests a potential primary vitamin K metabolism or absorption issue in these cats.
    • Long-term vitamin K1 supplementation may be necessary for affected Devon Rex cats.
    • Further research into the specific mechanisms of vitamin K metabolism in this breed is warranted.