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Screening of antibiotics preferentially active against ras oncogene-expressed cells
K Suzukake-Tsuchiya1, Y Moriya, K Yamazaki
1Showa College of Pharmaceutical Sciences, Machida city, Tokyo, Japan.
The Journal of Antibiotics
|November 1, 1990
Abstract:
During the course of in vitro screening of agents which are preferentially active against ras oncogene-expressed cells, a new anthracycline (identified as 2-demethylsteffimycin D) and a heptaene (possibly a new member of partricins) were isolated from microbial fermentation broths. Among known compounds tested, 5-fluorouracil, 5-fluorodeoxyuridine and oxanosine showed high selectivity towards ras oncogene-expressed cells.