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Immunomodulations induced in rats by exercise on a treadmill.
1Laboratoire de Physiologie des Adaptations, UFR Cochin-Port Royal, Université Paris V, France.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1990
Summary
Different treadmill exercise routines impact rat immune responses. Chronic exercise, particularly, alters T-cell blastogenesis, suggesting a role for corticosteroids in these immunomodulations.
Area of Science:
- Immunology
- Exercise Physiology
- Endocrinology
Background:
- Treadmill exercise is known to modulate immune function.
- The specific effects of different exercise regimens on immune parameters require further elucidation.
Purpose of the Study:
- To investigate the immunomodulatory effects of various treadmill exercise regimens in rats.
- To explore the role of corticosteroids in exercise-induced alterations of splenic T-cell blastogenesis.
Main Methods:
- Rats were subjected to distinct treadmill exercise protocols: T-15 (60 min at 15 m/min), T-10 (180 min at 10 m/min), and T-15-6 (60 min/day at 15 m/min for 6 days).
- Immune responses, including mononuclear spleen cell counts and T-cell blastogenesis, were assessed.
- Aminoglutethimide was administered to T-15-6 rats to investigate the involvement of corticosteroids.
Main Results:
- The T-10 regimen decreased mononuclear spleen cell counts and increased T-cell blastogenesis.
- The T-15-6 regimen significantly decreased T-cell blastogenesis.
- Aminoglutethimide administration reversed the decrease in T-cell blastogenesis in T-15-6 rats, indicating corticosteroid involvement.
Conclusions:
- Exercise-induced immunomodulation in rats is dependent on the specific treadmill exercise regimen.
- Chronic exercise alters splenic T-cell blastogenesis, and corticosteroids play a significant role in this alteration.