The participation of monoaminergic central mechanisms on adenohypophyseal secretion

In acute and chronic experiments in rats has been studied the action of drugs influencing central neuro-transmitter on the functional activity of hypophysis-adrenal and hypophysis-gonadal system. Evidence has been obtained that central neurotransmitters participate in the control of ACTH-glucocorticoids secretion. However, there is no clear correlation between noradrenaline and serotonin level in the brain and the degree of reaction of pituitary-adrenal complex to stimuli. Pharmacological analysis of nervous regulation of gonadotropic hypophysis function has revealed the significance of adrenergic mediation in the mechanism of feedback action of sex hormones and in the mechanism of limbic influences on hypothalamic regulation of gonadotropin secretion.