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Updated: May 21, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Efficacy of popliteal block in postoperative pain control after ankle fracture fixation: a prospective randomized
Rachel Y Goldstein1, Nicole Montero, Sudheer K Jain
1Department of Orthopaedics, NYU Medical Center, New York, NY, USA.
Objectives:
To compare postoperative pain control in patients treated surgically for ankle fractures who receive popliteal blocks with those who received general anesthesia alone.
Design:
Institutional Review Board approved prospective randomized study.
Setting:
Metropolitan tertiary-care referral center.
Patients:
All patients being treated with open reduction internal fixation for ankle fractures who met inclusion criteria and consented to participate were enrolled.
Interventions:
Patients were randomized to receive either general anesthesia (GETA) or intravenous sedation and popliteal block.
Main Outcome Measures:
Patients were assessed for duration of procedure, total time in the operating room, and postoperative pain at 2, 4, 8, 12, 24, and 48 hours after surgery using a visual analog scale.
Results:
Fifty-one patients agreed to participate in the study. Twenty-five patients received popliteal block, while 26 patients received GETA. There were no anesthesia-related complications. At 2, 4, and 8 hours postoperatively, patients who underwent GETA demonstrated significantly higher pain. At 12 hours, there was no significant difference between the 2 groups with regard to pain control. However, by 24 hours, those who had received popliteal blocks had significantly higher pain with no difference by 48 hours.
Conclusions:
Popliteal block provides equivalent postoperative pain control to general anesthesia alone in patients undergoing operative fixation of ankle fractures. However, patients who receive popliteal blocks do experience a significant increase in pain between 12 and 24 hours. Recognition of this "rebound pain" with early narcotic administration may allow patients to have more effective postoperative pain control.
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