Related Experiment Video
Updated: May 21, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Bacterial adhesion forces with substratum surfaces and the susceptibility of biofilms to antibiotics
Agnieszka K Muszanska1, M Reza Nejadnik, Yun Chen
1Department of Biomedical Engineering, W. J. Kolff Institute, University Medical Center Groningen, and University of Groningen, Groningen, The Netherlands.
Abstract:
Biofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa adhered more weakly to brush-coated silicone rubber (-0.05 ± 0.03 to -0.51 ± 0.62 nN) than to uncoated silicone rubber (-1.05 ± 0.46 to -5.1 ± 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.
More Related Videos
06:36Establishing the Minimal Bactericidal Concentration of an Antimicrobial Agent for Planktonic Cells (MBC-P) and Biofilm Cells (MBC-B)
Published on: January 2, 2014
10:17Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
Published on: October 9, 2016
Related Concept Videos
Biofilms
Clinical Significance of Antibiotic Resistance
Development of Antibiotic Resistance
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Mechanism of Antibiotic Resistance in MRSA
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...