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Total synthesis of (-)-FR901483
Ai-Jun Ma1, Yong-Qiang Tu, Jin-Bao Peng
1State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
Organic Letters
|June 28, 2012
Abstract:
A total synthesis of the immunosuppressive alkaloid (-)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product 1.
