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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

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Updated: May 21, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Proteomic updates on sepsis.

Rodrigo Siqueira-Batista1, Eduardo Gomes de Mendonça, Andréia Patrícia Gomes

  • 1Department of Medicine and Nursing and at the Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil. rsbatista@ufv.br

Revista Da Associacao Medica Brasileira (1992)
|June 28, 2012
PubMed
Summary
This summary is machine-generated.

Proteomics offers a promising approach to understanding sepsis by identifying key proteins. This can improve diagnosis, treatment, and patient outcomes in clinical practice.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Clinical Medicine

Background:

  • Proteomic analysis techniques have advanced, enhancing our understanding of molecular pathways.
  • Identifying proteins involved in cell signaling and post-translational modifications is crucial for disease characterization.
  • Sepsis research benefits from documenting specific protein expressions to understand its complexities.

Purpose of the Study:

  • To review the applications of proteomic studies in sepsis.
  • To highlight the potential of proteomics in elucidating sepsis pathophysiology, diagnosis, therapy, and prognosis.
  • To discuss the clinical relevance of proteomic findings in managing septic patients.

Main Methods:

  • Review of current literature on proteomic analysis in sepsis.
  • Analysis of studies focusing on protein identification and characterization in septic conditions.
  • Synthesis of findings related to cell signaling and post-translational modifications in sepsis.

Main Results:

  • Proteomics aids in identifying specific biological markers for sepsis.
  • Documenting protein expression patterns can elucidate pathophysiological aspects of sepsis.
  • Preliminary studies suggest proteomics can improve diagnostic and prognostic capabilities for sepsis.

Conclusions:

  • Proteomics holds significant promise for advancing the understanding and management of sepsis.
  • Further research is needed to translate proteomic findings into routine clinical practice for septic patients.
  • Proteomic insights can lead to better therapeutic strategies and improved patient outcomes in sepsis.