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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Bilateral inferior petrosal sinus sampling with desmopressin
Amy R Deipolyi1, Joshua A Hirsch, Rahmi Oklu
1Department of Radiology, Division of Vascular Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Journal of Neurointerventional Surgery
|June 28, 2012
Summary
Desmopressin can effectively stimulate pituitary adrenocorticotropic hormone secretion for bilateral inferior petrosal sinus sampling when corticotropin-releasing hormone is unavailable. This alternative offers reliable results without additional side effects.
Area of Science:
- Endocrinology
- Diagnostic Procedures
Background:
- Bilateral inferior petrosal sinus sampling (BIPSS) is a standard diagnostic procedure.
- Corticotropin-releasing hormone (CRH) is typically used to stimulate adrenocorticotropic hormone (ACTH) secretion during BIPSS.
- CRH is currently unavailable in the USA, necessitating alternative stimulation agents.
Purpose of the Study:
- To describe the use of desmopressin as a substitute for CRH in BIPSS.
- To evaluate the efficacy and safety of desmopressin in stimulating ACTH secretion.
Main Methods:
- Technical note detailing the application of desmopressin during BIPSS.
- Measurement of pituitary adrenocorticotropic hormone secretion following desmopressin administration.
Main Results:
- Desmopressin reliably stimulated adrenocorticotropic hormone secretion.
- No additional side effects were observed with desmopressin use.
Conclusions:
- Desmopressin is a viable and effective alternative to CRH for stimulating ACTH secretion in BIPSS.
- The use of desmopressin in BIPSS provides reliable diagnostic results safely.