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Modeling the Functional Network for Spatial Navigation in the Human Brain

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Published on: October 13, 2023

A framework for interpreting functional networks in schizophrenia.

Peter C Williamson¹, John M Allman

¹Tanna Schulich Chair in Neuroscience and Mental Health, University of Western Ontario, London ON, Canada.

Frontiers in Human Neuroscience

|June 28, 2012

Summary

This summary is machine-generated.

Schizophrenia research is advancing with neuroimaging, revealing brain network roles. New models suggest distinct networks for schizophrenia and mood disorders, impacting self-representation.

Keywords:

bipolar disorder default mode network diffusion tensor imaging functional MRI major depressive disorder salience network schizophrenia voxel-based morphometry

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

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Published on: March 21, 2019

Area of Science:

Neuroscience
Psychiatry
Brain Imaging

Background:

Genetic factors explain little of schizophrenia.
Understanding schizophrenia requires characterizing neuronal networks.
Previous models were limited by evaluation methods.

Purpose of the Study:

Review neuroimaging literature on brain networks in neuropsychiatric disorders.
Evaluate current models of brain networks in schizophrenia.
Propose alternative network models for schizophrenia and mood disorders.

Main Methods:

Review of voxel-based morphometry (VBM) studies.
Review of diffusion tensor imaging (DTI) studies.
Review of resting-state functional magnetic resonance imaging (rs-fMRI) studies.

Main Results:

The salience network plays a role, but interactions with default mode and executive control networks are insufficient to explain schizophrenia.
Schizophrenia may involve a network for directed effort (dorsal ACC, PCC, auditory cortex, hippocampus).
Mood disorders may involve a network for emotional encoding (ventral ACC, OFC, amygdala).

Conclusions:

Current network models partially explain schizophrenia but do not fully differentiate it from other disorders.
A uniquely human network for directed effort may underlie schizophrenia.
Distinct networks for directed effort and emotional encoding interact with other brain regions to enable self-representation.