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A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
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Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
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Treatment Resistant Cancers02:56

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Peripheral Artery Disease III: Interprofessional Care01:27

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Related Experiment Video

Updated: May 21, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

Intravenous pamidronate for refractory lymphedema.

A A Beigi1, A M Sadeghi, H Masoudpour

  • 1Department of Vascular Surgery, Isfahan University of Medical Sciences, Alzahra Hospital, Isfahan, Iran.

Iranian Red Crescent Medical Journal
|June 28, 2012
PubMed
Summary

Pamidronate treatment significantly improved limb volume, circumference, and patient satisfaction in refractory lymphedema cases. This suggests pamidronate is a promising addition to conservative lymphedema therapies.

Keywords:
BisphosphonatePamidronateRefractory lymphedema

Related Experiment Videos

Last Updated: May 21, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

Area of Science:

  • Pharmacology
  • Vascular Medicine
  • Clinical Therapeutics

Background:

  • Pamidronate has shown efficacy in reducing pain and swelling associated with reflex sympathetic dystrophy.
  • Refractory lymphedema presents a significant clinical challenge, necessitating novel treatment approaches.
  • The potential of pamidronate as a novel therapeutic agent for lymphedema warrants investigation.

Purpose of the Study:

  • To evaluate the therapeutic effectiveness of pamidronate in patients with refractory lower limb lymphedema.
  • To assess the safety and potential side effects of pamidronate administration for lymphedema.

Main Methods:

  • A cohort of twelve patients with lower limb refractory lymphedema was enrolled in the study.
  • Participants received monthly intravenous pamidronate infusions over three consecutive months.
  • Outcomes were assessed using the Visual Analog Scale (VAS) for discomfort, physician global assessment, limb volume, and circumference measurements.

Main Results:

  • Significant improvements were observed in limb volume and circumference.
  • Patient-reported satisfaction levels demonstrated a significant increase post-treatment.
  • Pamidronate administration was associated with positive clinical outcomes in refractory lymphedema.

Conclusions:

  • Pamidronate, when integrated with conservative management strategies, demonstrates potential in reducing lymphedema.
  • The addition of pamidronate may enhance patient comfort and clinical outcomes in lymphedema management.
  • Further research is warranted to establish optimal dosing and long-term efficacy.